反应详情

A mixture of 160 parts of 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane, 72 parts of hydrochloric acid, 800 parts of ethanol and 800 parts of water is stirred and refluxed for 2 h. 30. Then there are added dropwise 72 parts of sulfuric acid. Upon completion, stirring is continued at reflux temperature for one hour. The reaction mixture is cooled, poured onto water and the product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The residue is fractionated, yielding 68.5 parts of 4-(4-fluorophenyl)cyclohexanone; b.p. 110° C. at 1 mm. pressure.

1. temperaturerefluxed for 2 h
2. stirringUpon completion, stirring
3. temperatureat reflux temperature for one hour
4. temperatureThe reaction mixture is cooled
5. additionpoured onto water
6. extractionthe product is extracted with trichloromethane
7. washThe extract is washed with water
8. customdried
9. filtrationfiltered
10. customevaporated