Methylamine → N,2-Dimethyl-3-pyridinecarboxamide
Reaction equation
[CH3:1][C:2]1[N:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4](OCC)=[O:5].[CH3:13][NH2:14]>>[CH3:13][NH:14][C:4](=[O:5])[C:3]1[CH:9]=[CH:10][CH:11]=[N:12][C:2]=1[CH3:1]Participants
3
Procedure
200 g. (1.21 mol) of ethyl 2-methylnicotinate (Compound XI) and 1 l. of 40% aqueous methylamine were heated at 40° C. for 4 hours. The reaction mixture was stripped at reduced pressure to obtain the crude product (197.8 g.) as a thick oil which was distilled at 121°-133° C./0.18 mm. Hg. to give the product (175.8 g.), m.p. 69°-72° C.
Sources & evidence
- ORD record
- ord-f81a2d9df9e84a62826d2c6e0f9c9354
- Source dataset
- uspto-grants-1982_05
- Patent number
- US04329349
Reaction notes
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