反应详情

温度

20 °C

32.8 gm (0.1 mol) of 6-[4-(2-pyridyl-mercapto)-butoxy]-3,4-dihydro-carbostyril were dissolved in 330 ml of glacial acetic acid, and 10.2 gm (0.105 mol) of 35% hydrogen peroxide were added. The solution was stirred for 15 hours at about 20° C. The glacial acetic acid was distilled off at 60° C. in vacuo, the residue was washed with ether, and the thus obtained crude product was recrystallized twice from xylene in the presence of activated charcoal. Colorless crystals with a melting point of 144.5°-146° C. were obtained. Yield: 27.5 gm (79.8% of theory).

1. distillationThe glacial acetic acid was distilled off at 60° C. in vacuo
2. washthe residue was washed with ether
3. customthe thus obtained crude product
4. customwas recrystallized twice from xylene in the presence of activated charcoal
5. customColorless crystals with a melting point of 144.5°-146° C. were obtained