8-Hydroxy-3,4-dihydroquinolin-2(1h)-one → 8-(4-Phenylmercapto-butoxy)-3,4-dihydro-carbostyril

HRID 1065356Notes

Reaction equation

HRID 1065356 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.[C:13]1([S:19][CH2:20][CH2:21][CH2:22][CH2:23]Br)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19][CH2:20][CH2:21][CH2:22][CH2:23][O:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[NH:10][C:9](=[O:12])[CH2:8][CH2:7]3)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 2682398-Hydroxy-3,4-dihydroquinolin-2(1h)-oneHCID 111841484-Phenylmercapto-butylbromide

Product 1

HCID 539181468-(4-Phenylmercapto-butoxy)-3,4-dihydro-carbostyril

Procedure

Prepared analogous to Example 4 from 8-hydroxy-3,4-dihydro-carbostyril (see J. D. Loudon et al., J. Chem. Soc. 1955, 743-744) and 4-phenylmercapto-butyl bromide (bp. 96°-103° C. at 0.02 mm Hg).

Sources & evidence

ORD record
ord-33890bda7f1745d5bd6ceee1710694e2
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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