Hydrogen Peroxide → 5-(4-Phenylsulfinyl-butoxy)-carbostyril

HRID 1065371Notes

Reaction equation

HRID 1065371 reaction equation
[OH:1]O.[C:3]1([S:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.O>[C:3]1([S:9]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)=[O:1])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 784Hydrogen PeroxideHCID 538402795-(4-Phenylmercapto-butoxy)-carbostyril

Product 1

HCID 205401285-(4-Phenylsulfinyl-butoxy)-carbostyril

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

0.165 ml of 30% hydrogen peroxide, dissolved in 8 ml of glacial acetic acid, were added to 0.56 gm of 5-(4-phenylmercapto-butoxy)-carbostyril. The mixture was diluted with water and extracted twice with chloroform. The chloroform extract was washed with dilute sodium carbonate solution and with water, dried over magnesium sulfate and evaporated. The residue was admixed with ethyl acetate, yielding colorless crystals with a melting point of 155°-157° C.

Workup

  1. extractionextracted twice with chloroform
  2. extractionThe chloroform extract
  3. washwas washed with dilute sodium carbonate solution and with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customyielding colorless crystals with a melting point of 155°-157° C.

Sources & evidence

ORD record
ord-6e5d00fc9ec0487eaf7db48c123f4ebf
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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