6-(4-Phenylsulfonyl-butoxy)-carbostyril → 6-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

HRID 1065379Notes

Reaction equation

HRID 1065379 reaction equation
[C:1]1([S:7]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[NH:21][C:20](=[O:25])[CH:19]=[CH:18]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:1]1([S:7]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[NH:21][C:20](=[O:25])[CH2:19][CH2:18]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 205400406-(4-Phenylsulfonyl-butoxy)-carbostyrilHCID 178418361HCID 178418361, compound

Product 1

HCID 205400496-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

107 mgm of 6-(4-phenylsulfonyl-butoxy)-carbostyril were suspended in 15 ml of methanol, the suspension was admixed with 40 mgm of palladium-on-charcoal, and the mixture was hydrogenated at 50° C. and a hydrogen pressure of 2.5 bar for 14 hours. After filtering off the catalyst and evaporating the clear solution, a colorless crystalline residue was obtained.

Workup

  1. customwas hydrogenated at 50° C.
  2. filtrationAfter filtering off the catalyst
  3. customevaporating the clear solution
  4. customa colorless crystalline residue was obtained

Sources & evidence

ORD record
ord-48360c24842a4da0ac8a27e0a38591ed
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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