1-(p-Methoxyphenyl)-2-propanone → HCID 2846382, compound

HRID 1065478Notes

Reaction equation

HRID 1065478 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=O)[CH3:11])=[CH:5][CH:4]=1.[C:13]1([CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:20][CH2:21][NH2:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>[Pt]=O.C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([NH:22][CH2:21][CH2:20][CH:19]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH3:11])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 796983,3-Diphenylpropylamine

Product 1

HCID 2846382HCID 2846382, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

The starting material is prepared as follows: the mixture of 246.3 g of p-methoxyphenylacetone, 317 g of 3,3-diphenylpropylamine and 1,000 ml of anhydrous ethanol is hydrogenated at 20° and 3.4 atm. over 5 g of platinum oxide. After the theoretical amount of hydrogen has been absorbed (ca 4,000 ml), the mixture is filtered and the filtrate evaporated at 60°, to yield the 1-(4-methoxyphenyl)-2-(3,3-diphenylpropylamino)-propane as an oil.

Workup

  1. customThe starting material is prepared
  2. customis hydrogenated at 20°
  3. customAfter the theoretical amount of hydrogen has been absorbed (ca 4,000 ml)
  4. filtrationthe mixture is filtered
  5. customthe filtrate evaporated at 60°

Sources & evidence

ORD record
ord-0c25e945f6c54e47ae9a055b2a6f4f6f
Source dataset
uspto-grants-1982_05
Patent number
US04329367

Reaction notes

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