Hydrochloric Acid → HCID 57063205, compound

HRID 1065482Notes

Reaction equation

HRID 1065482 reaction equation
[CH3:1][N:2]([C:13]1[N:14]=[N:15][C:16](N2CCOCC2)=[CH:17][CH:18]=1)[N:3]=[C:4]1[CH2:9][CH:8]2[C:10]([CH3:12])([CH3:11])[CH:5]1[CH2:6][CH2:7]2.[ClH:25]>C(Cl)(Cl)Cl>[CH3:1][N:2]([C:13]1[N:14]=[N:15][C:16]([Cl:25])=[CH:17][CH:18]=1)[N:3]=[C:4]1[CH2:9][CH:8]2[C:10]([CH3:12])([CH3:11])[CH:5]1[CH2:6][CH2:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56974780HCID 56974780, compound

Product 1

HCID 57063205HCID 57063205, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A mixture of 32.9 g (0.1 moles) of 1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-morpholino-3-pyridazinyl)-hydrazine (prepared by the process of Example 8, Step b), 660 ml of chloroform and 660 ml of concentrated hydrochloric acid is heated at 60° while stirring under a nitrogen atmosphere for 6 hours in such a way that the chloroform layer is separated from the reaction mixture every hour and replaced by fresh solvent (660 ml). The camphor recovered can be condensed with 6-chloro-3-pyridazinylhydrazine to give pure 1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-chloro-3-pyridazinyl)-hydrazine in 65-72% yield.

Workup

  1. temperatureis heated at 60°
  2. customis separated from the reaction mixture every hour
  3. customThe camphor recovered can
  4. customcondensed with 6-chloro-3-pyridazinylhydrazine

Sources & evidence

ORD record
ord-54a2c41ca62c4849a5041b055c6c9b77
Source dataset
uspto-grants-1982_05
Patent number
US04329457

Reaction notes

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