Sodium Hydroxide → HCID 178462978, compound

HRID 1065489Notes

Reaction equation

HRID 1065489 reaction equation
[SH:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[C:5]([OH:11])=[N:4][N:3]=1.[OH-].[Na+].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[S:22][CH2:23][C:24]([NH:26][CH:27]1[C:42](=[O:43])[N:29]2[C:30]([C:39]([OH:41])=[O:40])=[C:31]([CH2:34]OC(=O)C)[CH2:32][S:33][C@H:28]12)=[O:25].[Na]>O>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[S:22][CH2:23][C:24]([NH:26][CH:27]1[C:42](=[O:43])[N:29]2[C:30]([C:39]([OH:41])=[O:40])=[C:31]([CH2:34][S:1][C:2]3[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[C:5]([OH:11])=[N:4][N:3]=3)[CH2:32][S:33][C@H:28]12)=[O:25]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 70540661HCID 70540661, compoundHCID 178462989HCID 178462989, compound

Product 1

HCID 178462978HCID 178462978, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 12 ml. of water were added with stirring 571 mg. of 3-mercapto-4-ethyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazine. The pH of the resulting mixture was 2.3 and was adjusted to 6.6 by addition of 2.9 ml. of 1 N sodium hydroxide. 7-(2,5-Dichlorophenylthio)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid, sodium salt (1.54 g., 3 mmol.) was added, and the resulting mixture was treated in accordance with the procedure described in Example 8 to obtain 7-(2,5-dichlorophenylthio)acetamido-3-(4-ethyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazin-3-ylthio)methyl-3-cephem-4-carboxylic acid.

Workup

  1. additionwas adjusted to 6.6 by addition of 2.9 ml
  2. additionthe resulting mixture was treated in accordance with the procedure

Sources & evidence

ORD record
ord-f6ace3c87f5b4f49adc3b85a6f878eb3
Source dataset
uspto-grants-1982_05
Patent number
US04329454

Reaction notes

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