Hydrogen Peroxide → HCID 12593098, compound

HRID 1065491Notes

Reaction equation

HRID 1065491 reaction equation
[CH3:1][N:2]([CH3:18])[C:3]1[CH:4]=[CH:5][C:6]2[CH:7]=[C:8]3[S:17][CH2:16][CH2:15][CH2:14][N:9]3[C:10](=[O:13])[C:11]=2[CH:12]=1.[OH:19]O>C(O)(=O)C>[CH3:1][N:2]([CH3:18])[C:3]1[CH:4]=[CH:5][C:6]2[CH:7]=[C:8]3[S:17](=[O:19])[CH2:16][CH2:15][CH2:14][N:9]3[C:10](=[O:13])[C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 12593081HCID 12593081, compound

Product 1

HCID 12593098HCID 12593098, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 550 mg. of 8-dimethylamino-6-oxo-3,4-dihydro-2H,6H-1,3-thiazino[3,2-b]isoquinoline, 10 ml. of acetic acid, and 0.41 ml. of a 35% aqueous hydrogen peroxide solution was stirred at 20°-30° C. After one hour, the reaction mixture was filtered and after adding 10 ml. of water to the filtrate, anhydrous sodium carbonate was added to it to make the filtrate basic. The precipitates formed were recovered by filtration and dried. By recrystallizing from benzene-hexane, 300 mg. of 8-dimethylamino-6-oxo-3,4-dihydro-2H,6H-1,3-thiazino[3,2-b]isoquinoline-1-oxide was obtained.

Workup

  1. additionA mixture of 550 mg
  2. filtrationthe reaction mixture was filtered
  3. additionafter adding 10 ml
  4. additionof water to the filtrate, anhydrous sodium carbonate was added to it
  5. customThe precipitates formed
  6. filtrationwere recovered by filtration
  7. customdried
  8. customBy recrystallizing from benzene-hexane, 300 mg

Sources & evidence

ORD record
ord-ecd9b208b83845f68673fa91a2ff9817
Source dataset
uspto-grants-1982_05
Patent number
US04329455

Reaction notes

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