Sodium Hydroxide → HCID 20539740, compound

HRID 1065653Notes

Reaction equation

HRID 1065653 reaction equation
C([O:3][C:4](=[O:22])[C:5]([NH:7][C:8]1[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]2[C:9]=1[C:10](=[O:21])[CH2:11][CH:12]2[CH2:18][CH2:19][CH3:20])=[O:6])C.[OH-].[Na+]>CO>[CH3:17][C:14]1[CH:15]=[CH:16][C:8]([NH:7][C:5](=[O:6])[C:4]([OH:22])=[O:3])=[C:9]2[C:13]=1[CH:12]([CH2:18][CH2:19][CH3:20])[CH2:11][C:10]2=[O:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53863676HCID 53863676, compound

Product 1

HCID 20539740HCID 20539740, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.6 g N-(7-methyl-3-oxo-1-propyl-4-indanyl)oxamic acid ethyl ester in 100 ml methanol is heated at reflux with 5.28 ml of 1 M aqueous NaOH for 30 minutes. The solution is concentrated, diluted with water, filtered through a filtering aid such as Hyflo (Registered Trade Mark), and made acid with 2 N HCL. The title compound is filtered off and dried. M.Pt. 157°-158°.

Workup

  1. concentrationThe solution is concentrated
  2. additiondiluted with water
  3. filtrationfiltered through a filtering aid such as Hyflo (Registered Trade Mark)
  4. filtrationThe title compound is filtered off
  5. customdried

Sources & evidence

ORD record
ord-c022c94bab7342eeac70a3671c3f5fa2
Source dataset
uspto-grants-1982_05
Patent number
US04330555

Reaction notes

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