Sodium Hydroxide → HCID 12961958, compound

HRID 1065696Notes

Reaction equation

HRID 1065696 reaction equation
C([O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][C@@H:13]([OH:25])[C@H:14]2[NH2:24])[CH2:6]1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:24][C@@H:14]1[C@H:13]([OH:25])[CH2:12][C@H:11]2[C@H:10]3[C@H:19]([CH2:18][CH2:17][C@:15]12[CH3:16])[C@:20]1([CH3:23])[C@H:7]([CH2:6][C@@H:5]([OH:4])[CH2:22][CH2:21]1)[CH2:8][CH2:9]3

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12961961HCID 12961961, compound

Product 1

HCID 12961958HCID 12961958, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrolysis of 17α-amino-5α-androstane-3β,16α-diol 3-acetate (4.8 g) with sodium hydroxide (4 N) and ethanol at reflux temperature gave 17α-amino-5α-androstane-3β,16α-diol (3.4 g). Crystallisation from ethanol yielded an analytical sample, m.p. 220°-225° C.

Workup

  1. temperatureat reflux temperature

Sources & evidence

ORD record
ord-b21bd65b87bb48ad8a6311e48df10149
Source dataset
uspto-grants-1982_05
Patent number
US04330539

Reaction notes

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