Methanesulfonic Acid → HCID 12961986, compound

HRID 1065711Notes

Reaction equation

HRID 1065711 reaction equation
[CH3:1][NH:2][C@H:3]1[C@H:8]([OH:9])[CH2:7][C@H:6]2[C@H:10]3[C@H:19]([CH2:20][CH2:21][C@:4]12[CH3:5])[C:18]1[CH:17]=[CH:16][C:15]([OH:22])=[CH:14][C:13]=1[CH2:12][CH2:11]3.[CH3:23][S:24]([OH:27])(=[O:26])=[O:25]>>[CH3:23][S:24]([OH:27])(=[O:26])=[O:25].[CH3:1][NH:2][C@H:3]1[C@H:8]([OH:9])[CH2:7][C@H:6]2[C@H:10]3[C@H:19]([CH2:20][CH2:21][C@:4]12[CH3:5])[C:18]1[CH:17]=[CH:16][C:15]([OH:22])=[CH:14][C:13]=1[CH2:12][CH2:11]3

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 986666317 beta-(Methylamino)estra-1(10),2,4-triene-3,16α-diol

Product 1

HCID 12961986HCID 12961986, compound

Procedure

In a similar way as described in Example XXIV 17β-methylamino-oestra-1,3,5(10)-triene-3,16α-diol was reacted with methanesulphonic acid to give the title compound, m.p. 268°-270° C.; [α]D +43.8° (c 1.05 in EtOH).

Sources & evidence

ORD record
ord-690df5fd5af04e84a4f0686dcb1b1043
Source dataset
uspto-grants-1982_05
Patent number
US04330539

Reaction notes

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