Maleic Anhydride → HCID 12854637, Verbindung

HRID 1065811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1065811
[CH2:1]([NH:9][C:10]([C@@H:12]1[CH2:14][C@H:13]1[C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:22]1(=[O:28])[O:27][C:25](=[O:26])[CH:24]=[CH:23]1>C1C=CC=CC=1>[CH2:1]([NH:9][C:10]([C@@H:12]1[CH2:14][C@H:13]1[C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:28])/[CH:23]=[CH:24]\[C:25]([OH:27])=[O:26])=[CH:17][CH:16]=1)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

4

Edukt 2

HCID 7923Maleic AnhydrideHCID 12854635trans-N-octyl-2-(4-aminophenyl)cyclopropanecarboxamide

Produkt 1

HCID 12854637HCID 12854637, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a refluxing solution of 1.6 g. of trans-N-octyl-2-(4-aminophenyl)cyclopropanecarboxamide in 30 ml. of benzene was added 598 mg. of maleic anhydride all at once. Refluxing was continued for 10 minutes, and then the reaction mixture was cooled to room temperature and the solvent was removed in vacuo. The residue was recrystallized twice from ethanol to give 930 mg. of the title compound as a white solid, m.p. 178.5°-179.5° C. The IR spectrum (KBr disc) showed absorptions at 3280, 2925, 1725, 1640 and 1550 cm-1.

Aufarbeitung

  1. temperatureRefluxing
  2. customthe solvent was removed in vacuo
  3. customThe residue was recrystallized twice from ethanol
  4. customto give 930 mg

Quellen und Nachweise

ORD-Eintrag
ord-342ea389f50045fcb61e1fde7795f419
Quelldatensatz
uspto-grants-1982_05
Patentnummer
US04331683

Notizen zur Reaktion

Wird geladen…