Hydrochloric Acid → HCID 12850740, compound

Participants

Reaction Steps

4-(3-Amino-4-nitrophenyl)-2,6-dimethylpyridine was prepared in two steps by first nitrating (with 45 ml. of concentrated nitric acid) 10 g. of 3-(2,6-dimethyl-4-pyridinyl)acetanilide using the procedure given above in the second paragraph of Example A-3 to produce 5.2 g. of 4-(3-acetylamino-4-nitrophenyl)-2,6-dimethylpyridine and hydrolyzing the latter compound (41.2 g.) with 6 N aqueous hydrochloric acid to produce 4-(3-amino-4-nitrophenyl)-2,6-dimethylpyridine (34.2 g.), m.p. 226°-229° C.

Provenance & Evidence