Hydrochloric Acid → HCID 12850740, compound

HRID 1065840Notes

Reaction equation

HRID 1065840 reaction equation
[N+]([O-])(O)=O.C([NH:8][C:9]1[CH:10]=[C:11]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([CH3:25])[CH:19]=2)[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])(=O)C.Cl>>[NH2:8][C:9]1[CH:10]=[C:11]([C:18]2[CH:19]=[C:20]([CH3:25])[N:21]=[C:22]([CH3:24])[CH:23]=2)[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 944Nitric AcidHCID 20535844HCID 20535844, compound

Product 1

HCID 12850740HCID 12850740, compound

Procedure

4-(3-Amino-4-nitrophenyl)-2,6-dimethylpyridine was prepared in two steps by first nitrating (with 45 ml. of concentrated nitric acid) 10 g. of 3-(2,6-dimethyl-4-pyridinyl)acetanilide using the procedure given above in the second paragraph of Example A-3 to produce 5.2 g. of 4-(3-acetylamino-4-nitrophenyl)-2,6-dimethylpyridine and hydrolyzing the latter compound (41.2 g.) with 6 N aqueous hydrochloric acid to produce 4-(3-amino-4-nitrophenyl)-2,6-dimethylpyridine (34.2 g.), m.p. 226°-229° C.

Workup

  1. customto produce 5.2 g

Sources & evidence

ORD record
ord-bce027843dc047d5a967e62862ec522e
Source dataset
uspto-grants-1982_05
Patent number
US04331671

Reaction notes

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