反应详情

温度

5 °C

A mixture of 3,6-dichloro-4-carboxy-pyridazine (20 g; 0.103 mole) and 22 ml of 98% hydrazine hydrate in 200 ml of 50% ethanol was refluxed, under stirring, for one hour. After cooling at 5° C., the solid precipitate was collected, washed with 20 ml of anhydrous ethanol. The solid was suspended in 100 ml of water, the mixture was brought to pH 1-2 with 23% HCl, after cooling at 5° C. the solid was filtered, dried under vacuum at 80° C. to give 18.29 g (93.4%) of the title compound, m.p. 198°-201° C.

1. temperaturewas refluxed
2. customthe solid precipitate was collected
3. washwashed with 20 ml of anhydrous ethanol
4. temperatureafter cooling at 5° C. the solid
5. filtrationwas filtered
6. customdried under vacuum at 80° C.