Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide → 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

HRID 1065914노트

반응식

HRID 1065914 반응식
Br.[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([O:8]CC)=[O:7]>[OH-].[Na+].O>[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 1

HCID 73668749Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide

생성물 1

HCID 1252162-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid수율 79.6%

시약·촉매·용매 2

HCID 962Water용매HCID 14798Sodium Hydroxide용매

실험 절차

Ethyl 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate hydrobromide (anti isomer) (15.5 g.) was dissolved in a solution of sodium hydroxide (4.4 g.) in water (150 ml.) and the resulting solution was stirred for 1 hour at ambient temperature. An insoluble material was filtered off and the filtrate was adjusted to pH 5.0 to precipitate crystals. The crystals were collected by filtration and dried to give 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (anti isomer) (8.0 g.).

후처리

  1. filtrationAn insoluble material was filtered off
  2. customto precipitate crystals
  3. filtrationThe crystals were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-0c6bd61b79c444738ed0d317a570f2ed
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04331664

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