反应详情

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride (from E14) (10 g) was hydrogenated over Adams' catalyst (0.25 g) at 300 psi in ethanol (250 ml) at 70° for 6 hours. The residue obtained after filtration and evaporation was taken up in a mixture of ethyl acetate and aqueous sodium carbonate, the organic layer was dried (Na2CO3) filtered and evaporated to give 4-chloro-2-(piperidine-4-carboxamido)anisole as a cream-coloured powder (7.4 g). (A portion was recrystallised from ethyl acetate to give white prisms, m.p. 124°-126°.)

1. customThe residue obtained
2. filtrationafter filtration and evaporation
3. additionwas taken up in a mixture of ethyl acetate and aqueous sodium carbonate
4. dry with materialthe organic layer was dried (Na2CO3)
5. filtrationfiltered
6. customevaporated