Toluene → (4-Isopropylthiazol-2-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

HRID 106597Notes

Reaction equation

HRID 106597 reaction equation
[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][O:14][C:15]3([CH2:16]2)[CH2:17][CH2:18][N:19]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:20][CH2:21]3)[s:7][cH:8]1.[Cl:43][CH2:44][Cl:45].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][O:14][C:15]3([CH2:16]2)[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]3)[s:7][cH:8]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57988958tert-Butyl 4-(4-isopropylthiazole-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57989334(4-Isopropylthiazol-2-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

Sources & evidence

ORD record
ord-07768073139e4766968b63671ab33078
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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