HCID 9927034, compound → HCID 9861986, compound

HRID 1066010Notes

Reaction equation

HRID 1066010 reaction equation
[C@@H:1]1([N:10]2[CH:18]=[N:17][C:16]3[C:11]2=[N:12][C:13]([C:20]#[C:21][CH2:22][CH3:23])=[N:14][C:15]=3[NH2:19])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]>CO.[C].[Pd]>[C@@H:1]1([N:10]2[CH:18]=[N:17][C:16]3[C:11]2=[N:12][C:13]([CH2:20][CH2:21][CH2:22][CH3:23])=[N:14][C:15]=3[NH2:19])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]

Participants

4

Reactant 1

HCID 9927034HCID 9927034, compound2×

Product 1

HCID 9861986HCID 9861986, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

9-(β-D-arabinofuranosyl)-2-(1-butyne-1-yl)adenine [compound 3] in an amount of 2 g was dissolved in 30 mL of 50% methanol, 10 mg of 10% palladium carbon were added thereto and the mixture was stirred at room temperature for 16 hours. The catalyst was filtered off, the filtrate was concentrated and the crystals separated out therefrom were collected. They were recrystallized from distilled water to give a compound 7 (1.95 g) as colorless needles: ps 9-(β-D-arabinofuranosyl)-2-butyladenine [compound 7]

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. customthe crystals separated out
  4. customtherefrom were collected
  5. customThey were recrystallized
  6. distillationfrom distilled water

Sources & evidence

ORD record
ord-cdbd7383819d49499aec321c6dbbec45
Source dataset
uspto-grants-2001_06
Patent number
US06242429B1

Reaction notes

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