4-(Quinolin-3-yl)piperidin-4-ol → 1-(3-(2-Tert-butylphenoxy)prop-1-yl)-4-hydroxy-4-(quinolin-3-yl)piperidine

HRID 1066079Notes

Reaction equation

HRID 1066079 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH2:13][CH2:14]Cl)([CH3:4])([CH3:3])[CH3:2].[OH:16][C:17]1([C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH2:13][CH2:14][N:20]1[CH2:21][CH2:22][C:17]([OH:16])([C:23]2[CH:24]=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:18][CH2:19]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 211980104-(Quinolin-3-yl)piperidin-4-olHCID 211981133-Chloropropyl 2-tert-butylphenyl ether

Product 1

HCID 98021501-(3-(2-Tert-butylphenoxy)prop-1-yl)-4-hydroxy-4-(quinolin-3-yl)piperidineYield 39%

Procedure

Beginning with 0.298 gm (1.3 mMol) 3-chloropropyl 2-tert-butylphenyl ether and 0.300 gm (1.3 mMol) 4-hydroxy-4-(quinolin-3-yl)piperidine, 0.212 gm (39%) of the title compound were recovered as a white, waxy solid.

Sources & evidence

ORD record
ord-6f8e1e14e946475bbcc8fdb505dda2c3
Source dataset
uspto-grants-2001_06
Patent number
US06242450B1

Reaction notes

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