Phosgene → HCID 178456962, compound

HRID 1066093Notes

Reaction equation

HRID 1066093 reaction equation
NC1C=C(C)C=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][C:21]=1[S:27]([NH:30][C:31]([NH:33][CH:34]([CH3:36])[CH3:35])=S)(=[O:29])=[O:28].C(Cl)(Cl)=O>>[Cl:26][C:25]1[C:20]2[NH:19][C:31]([NH:33][CH:34]([CH3:36])[CH3:35])=[N:30][S:27](=[O:29])(=[O:28])[C:21]=2[CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 4

HCID 6371PhosgeneHCID 75263Isopropyl IsothiocyanateHCID 114365382-Amino-4-methylbenzenesulfonamideHCID 21197874N-(2-amino-3-chlorobenzenesulfonyl)-N'-isopropylthiourea

Product 1

HCID 178456962HCID 178456962, compound

Procedure

Starting from 2-amino-4-methylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-3-chlorobenzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 124-125° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 204-206° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-03d968f72dbe4be291853f648f68b544
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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