Phosgene → HCID 178456961, compound

HRID 1066098Notes

Reaction equation

HRID 1066098 reaction equation
NC1C=CC(C(C)(C)C)=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:25][C:24]=1[S:33]([NH:36][C:37]([NH:39][CH:40]([CH3:42])[CH3:41])=S)(=[O:35])=[O:34].C(Cl)(Cl)=O>>[C:29]([C:26]1[CH:27]=[CH:28][C:23]2[NH:22][C:37]([NH:39][CH:40]([CH3:42])[CH3:41])=[N:36][S:33](=[O:35])(=[O:34])[C:24]=2[CH:25]=1)([CH3:32])([CH3:31])[CH3:30]

Participants

5

Reactant 4

HCID 6371PhosgeneHCID 75263Isopropyl IsothiocyanateHCID 21197855HCID 21197855, compoundHCID 21197876HCID 21197876, compound

Product 1

HCID 178456961HCID 178456961, compound

Procedure

Starting from 2-amino-5-tert-butylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-5-tert-butylbenzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 128-130° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 290-293° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-cca17fe217d34107be4107b1c7e02978
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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