Isopropyl Isothiocyanate → HCID 178456977, compound

HRID 1066099Notes

Reaction equation

HRID 1066099 reaction equation
NC1C=C(OC2C=CC=CC=2)C=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:25][C:26]1[CH:31]=[C:30]([O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:29]=[CH:28][C:27]=1[S:39]([NH:42][C:43]([NH:45][CH:46]([CH3:48])[CH3:47])=S)(=[O:41])=[O:40]>>[CH:46]([NH:45][C:43]1[NH:25][C:26]2[CH:31]=[C:30]([O:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH:29]=[CH:28][C:27]=2[S:39](=[O:41])(=[O:40])[N:42]=1)([CH3:48])[CH3:47]

Participants

4

Reactant 3

HCID 75263Isopropyl IsothiocyanateHCID 21197820HCID 21197820, compoundHCID 21197829HCID 21197829, compound

Product 1

HCID 178456977HCID 178456977, compound

Procedure

Starting from 2-amino-4-phenoxybenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-phenoxybenzenesulfonyl)-N′-isopropylthiourea was prepared. The impure crude product was used without purification. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 250-252° C.

Workup

  1. customwas prepared
  2. customThe impure crude product was used without purification

Sources & evidence

ORD record
ord-ad17b97b7e154f56b9b0d5ae92326cd0
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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