Hydrochloric Acid → HCID 178456965, compound

HRID 1066103Notes

Reaction equation

HRID 1066103 reaction equation
[CH:1]([NH:4][C:5]1[NH:10][C:9]2[CH:11]=[C:12]([CH2:15][C:16]([O:18]CC)=[O:17])[CH:13]=[CH:14][C:8]=2[S:7](=[O:22])(=[O:21])[N:6]=1)([CH3:3])[CH3:2].Cl>[OH-].[Na+]>[CH:1]([NH:4][C:5]1[NH:10][C:9]2[CH:11]=[C:12]([CH2:15][C:16]([OH:18])=[O:17])[CH:13]=[CH:14][C:8]=2[S:7](=[O:21])(=[O:22])[N:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178470588HCID 178470588, compound

Product 1

HCID 178456965HCID 178456965, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl (3-isopropylamino-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-6-yl)acetate (0.22 g) was stirred in 5 ml of 4M aqueous sodium hydroxide at room temperature for 1 h. The reaction mixture was then acidified with 4M hydrochloric acid. The resulting precipitate was collected by filtration, the filter cake was rinsed with a small amount of water and dried to give 0.17 g of the title compound, m.p. 262-264° C.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washthe filter cake was rinsed with a small amount of water
  3. customdried

Sources & evidence

ORD record
ord-94a53f7d195e423784b23861cdad8b1e
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

Loading…