Formic Acid → HCID 178456963, compound

HRID 1066106Notes

Reaction equation

HRID 1066106 reaction equation
[CH:1]([NH:4][C:5]1[NH:10][C:9]2[CH:11]=[C:12]([CH2:15][C:16]([NH2:18])=O)[CH:13]=[CH:14][C:8]=2[S:7](=[O:20])(=[O:19])[N:6]=1)([CH3:3])[CH3:2].C(O)=O.C=O>C(#N)C>[CH:1]([NH:4][C:5]1[NH:10][C:9]2[CH:11]=[C:12]([CH2:15][C:16]#[N:18])[CH:13]=[CH:14][C:8]=2[S:7](=[O:19])(=[O:20])[N:6]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 712FormaldehydeHCID 178456964HCID 178456964, compound

Product 1

HCID 178456963HCID 178456963, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A slurry of 2-(3-isopropylamino-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-6-yl)acetamide (50 mg) in a mixture of 0.8 ml of acetonitrile, 0.2 ml of formic acid and 25 mg of paraformaldehyde was heated at reflux for 16 h, and then evaporated to dryness. The residue was purified on a silica column eluted with dichloromethane-methanol (95:5) to give the title compound; m.p. 195-203° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. customevaporated to dryness
  4. customThe residue was purified on a silica column
  5. washeluted with dichloromethane-methanol (95:5)

Sources & evidence

ORD record
ord-8de77390e2bd4cbab416ceaca2d37f89
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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