Formic Acid → HCID 178456963, compound

Participants

Reaction Steps

A slurry of 2-(3-isopropylamino-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-6-yl)acetamide (50 mg) in a mixture of 0.8 ml of acetonitrile, 0.2 ml of formic acid and 25 mg of paraformaldehyde was heated at reflux for 16 h, and then evaporated to dryness. The residue was purified on a silica column eluted with dichloromethane-methanol (95:5) to give the title compound; m.p. 195-203° C.

Provenance & Evidence