O-Methylhydroxylamine hydrochloride → HCID 21197809, compound

HRID 1066108Notes

Reaction equation

HRID 1066108 reaction equation
Cl[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.Cl.[CH3:16][O:17][NH2:18]>>[Cl:12][C:10]1[CH:9]=[CH:8][C:6]2[NH:7][C:2]([NH:18][O:17][CH3:16])=[N:3][S:4](=[O:14])(=[O:13])[C:5]=2[CH:11]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 127001053,7-dichloro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 21197809HCID 21197809, compoundYield 57%

Procedure

Starting from 3,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (502 mg; 2 mmol) and O-methylhydroxylamine hydrochloride (300 mg) and with the use of the same procedure as in example 21, 280 mg (57%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 11.35 (s, 1H, NH), 11.28 (s, 1H, NH), 7.78 (d, 1H, H-8), 7.63 (dd, 2H, H-6 and H-5), 3.80 (s, 3H, CH3); 13C-NMR (DMSO-d6) ppm; 151.19, 132.79, 131.26, 127.10, 123.00, 120.83, 118.78, 63.25.

Sources & evidence

ORD record
ord-78f74ac46ef24a9386bdea01dea1a2dc
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

Loading…