2-Butanamine, 3,3-dimethyl- → HCID 178463650, compound

HRID 1066114Notes

Reaction equation

HRID 1066114 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[NH:6][C:7](Cl)=[N:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.[CH3:15][CH:16]([NH2:21])[C:17]([CH3:20])([CH3:19])[CH3:18]>>[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[NH:6][C:7]([NH:21][CH:16]([CH3:15])[C:17]([CH3:20])([CH3:19])[CH3:18])=[N:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 5209072-Butanamine, 3,3-dimethyl-HCID 21197745HCID 21197745, compound

Product 1

HCID 178463650HCID 178463650, compound

Procedure

Starting from 7-bromo-3-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (300 mg; 1.01 mmol) and 1,2,2-trimethylpropylamine (359 mg; 4.04 mmol) with the use of same procedure as in example 21 200 mg (54.9%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 10.35 (s, 1H, NH), 7.78 (d, 1H, H-8), 7.6 (dd, 1H, H-6), 7.12 (br d, 1H, H-5), 6.95 (br, 1H, NH), 3.72 (q, 1H, CH), 1.10 (d, 3H, CH3), 0.92 (s, 9H, 3×CH3); MS:EI/70eV: 361 (M+1), 304, 277, 236, 170, 116, 90, 44.

Sources & evidence

ORD record
ord-7da2e843a7a9419a89fad0651c44fcef
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

Loading…