Benzenebutanamine → HCID 178527191, compound

HRID 1066122Notes

Reaction equation

Cl[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.[C:15]1([CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:12][C:10]1[CH:9]=[CH:8][C:6]2[NH:7][C:2]([NH:25][CH2:24][CH2:23][CH2:22][CH2:21][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:3][S:4](=[O:14])(=[O:13])[C:5]=2[CH:11]=1

Participants

Reactant 2

HCID 83242Benzenebutanamine

HCID 127001053,7-dichloro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 178527191HCID 178527191, compound

Procedure

Starting from 3,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (300 mg; 1.19 mmol) and 4-phenylbutylamine (1.5 g; 4.12 mmol) and with the use of same procedure as in example 21 120 mg (27.7%) of the title compound was prepared.; 1H-NMR (DMSO-d6) ppm; 10.8 (s, 1H, NH), 7.75 (d, 1H, H-8), 7.60 (dd, 1H, H-5), 7.2 (m, 7H), 3.29 (t, 2H, CH2), 2.66 (t, 2H, CH2), 1.5 (m, 4H, 2×CH2); MS:EI/70eV: 363 (M+), 272, 259, 231, 180, 91, 44.

Sources & evidence

ORD record: ord-3251710fe85a42a19dc9a0e0f0658232
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06242443B1

Reaction notes

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