Isopropyl Isothiocyanate → HCID 178456982, compound

HRID 1066134Notes

Reaction equation

HRID 1066134 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[CH:14]([N:17]=[C:18]=S)([CH3:16])[CH3:15]>C(OCC)(=O)C>[Cl:8][C:6]1[C:5]([F:9])=[CH:4][C:3]2[S:10](=[O:12])(=[O:11])[N:13]=[C:18]([NH:17][CH:14]([CH3:16])[CH3:15])[NH:1][C:2]=2[CH:7]=1

Participants

4

Reactant 2

HCID 75263Isopropyl IsothiocyanateHCID 11401851HCID 11401851, compound

Product 1

HCID 178456982HCID 178456982, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared from 2-amino-4-chloro-5-fluorobenzenesulfonamide and isopropyl isothiocyanate by a method analogous to the one described in Example 4; m.p. 282-285° C. (ethyl acetate); 1H-NMR (DMSO-d6): δ 1.17 (d, 6H, CH(CH3)2), 3.92 (m, 1H, CH(CH3)2), 7.34 (br., 1H, NH), 7.45 (d, 1H, ArH), 7.76 (d, 1H, ArH), 10.44 (br.s, 1H, NH); MS: m/e 291/293 (M+); (C10H11N3Cl1F1O2S1) calc. C, 41.17; H, 3.80; N, 14.40; found C, 41.3; H, 3.8; N, 14.4.

Sources & evidence

ORD record
ord-da9585af2b044d38910f13cbecfabe14
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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