Isopropyl Isothiocyanate → HCID 178422570, compound

HRID 1066137Notes

Reaction equation

HRID 1066137 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH:13]([N:16]=[C:17]=S)([CH3:15])[CH3:14]>C(OCC)(=O)C>[CH:13]([NH:16][C:17]1[NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=2[S:9](=[O:10])(=[O:11])[N:12]=1)([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 75263Isopropyl IsothiocyanateHCID 2455842-Amino-5-methylbenzenesulfonamide

Product 1

HCID 178422570HCID 178422570, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared from 2-amino-5-methylbenzenesulfonamide and isopropyl isothiocyanate by a method analogous to the one described in Example 4; m.p. 266-268° C. (ethyl acetate); 1H-NMR (DMSO-d6): δ 1.16 (d, 6H, CH(CH3)2), 3.91 (m, 1H, CH(CH3)2), 6.92 (br.d, 1H, NH), 7.06 (d, 1H, ArH), 7.35 (dd, 1H, ArH), 7.45 (d, 1H, ArH), 10.20 (br.s, 1H, NH); MS: m/e 253 (M+, 44%); (C11H15N3O2S1) calc. C, 52.16; H, 5.97; N, 16.59; found C, 52.28; H, 6.19; N, 16.49.

Sources & evidence

ORD record
ord-a80f4e02de1e4babaabcf814834b2d9d
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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