反应详情

Ethyl 4-[3-(4-amino-3-hydroxybenzoyl)indol-1-yl]butanoate (30 g) was suspended in acetone (390 ml), potassium carbonate (23.8 g) and chlorobromopropane (24 ml) were added to the suspension. The mixture was stirred at room temperature for four hours. The reaction mixture was cooled and filtrated. The filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1), to thereby obtain 22.8 g of ethyl 4-{3-[4-amino-3-(3-chloropropoxy)benzoyl]indol-1-yl}butanoate as colorless prisms.

1. temperatureThe reaction mixture was cooled
2. filtrationfiltrated
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe resultant residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1)