反应详情

温度

50 °C

Zolpidem free base (1.0 g) is suspended in 10 ml of ethanol and heated at 50° C. until dissolution. Then, 0.32 g (molar equivalent) of concentrated hydrochloric acid is added and the solution stirred for 10 minutes. Then the bath is removed and the reaction mixture is allowed to cool to room temperature. Finally, the mixture is kept standing overnight at 4° C. The formed crystals are filtered off, washed with 3 ml of cold ethanol and dried at 40° C. in a vacuum oven to produce zolpidem hydrochloride hemiethanolate.

1. customThen the bath is removed
2. temperatureto cool to room temperature
3. waitFinally, the mixture is kept standing overnight at 4° C
4. filtrationThe formed crystals are filtered off
5. washwashed with 3 ml of cold ethanol
6. customdried at 40° C. in a vacuum oven