反应详情

One gram of zolpidem free base is dissolved in 10 ml of ethanol at 50° C. Then 0.313 g (a molar equivalent) of methane sulfonic acid is added at this temperature, the mixture is stirred for 5 minutes and evaporated to dryness under reduced pressure. The residue is treated with 10 ml of acetone, the remaining solid is filtered off and washed with 5 ml of acetone and dried in vacuum oven at 40° C. to yield zolpidem methanesulfonate. A representative DSC curve is shown in FIG. 12.

1. customevaporated to dryness under reduced pressure
2. additionThe residue is treated with 10 ml of acetone
3. filtrationthe remaining solid is filtered off
4. washwashed with 5 ml of acetone
5. customdried in vacuum oven at 40° C.