Hydrochloric Acid → HCID 21198552, compound

HRID 1066188Notes

Reaction equation

HRID 1066188 reaction equation
[C:1]([CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1)(O)=[O:2].[ClH:18].S(Cl)([Cl:21])=O>C(Cl)Cl>[ClH:21].[Cl:18][C:1]([CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1)=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 15818985HCID 15818985, compound

Product 1

HCID 21198552HCID 21198552, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1.46 g of 4-(2-carboxyethyl)-1-[(ethoxycarbonyl)methyl]-piperidine in 10 ml of methylene chloride is added 1 ml of saturated ethereal hydrochloric acid. 1.2 g of thionyl chloride are added and the mixture is stirred for 3 hours at ambient temperature. The reaction mixture is concentrated by evaporation and the residue is mixed twice with toluene and again concentrated by evaporation. The crude product is reacted further in Example 1 without purification.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. additionthe residue is mixed twice with toluene
  3. concentrationagain concentrated by evaporation
  4. customThe crude product is reacted further in Example 1 without purification

Sources & evidence

ORD record
ord-e9573fe2625d400dbaa13305e8498c87
Source dataset
uspto-grants-2001_06
Patent number
US06242466B1

Reaction notes

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