(3-Amino-2-methylphenyl)methanol → HCID 20660019, compound

HRID 1066250Notes

Reaction equation

HRID 1066250 reaction equation
[C:1]12([CH2:11][C:12](Cl)=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:15][C:16]1[C:17]([CH3:24])=[C:18]([CH:21]=[CH:22][CH:23]=1)[CH2:19][OH:20]>>[OH:20][CH2:19][C:18]1[C:17]([CH3:24])=[C:16]([NH:15][C:12](=[O:13])[CH2:11][C:1]23[CH2:10][CH:5]4[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]4)[CH2:2]2)[CH2:8]3)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 577175(3-Amino-2-methylphenyl)methanolHCID 27718821-Adamantaneacetyl chloride

Product 1

HCID 20660019HCID 20660019, compoundYield 27.1%

Procedure

Prepared according to the method of Example 1b) from 1-adamantaneacetyl chloride (2.0 g) and 3-amino-2-methylbenzyl alcohol (1.29 g). Silica gel chromatography, eluting with 5% ethylacetate in dichloromethane gave the title compound as a white solid (0.80 g).

Workup

  1. customPrepared
  2. washSilica gel chromatography, eluting with 5% ethylacetate in dichloromethane

Sources & evidence

ORD record
ord-f99f61b3cc4c4c12945881e5c0713b14
Source dataset
uspto-grants-2001_06
Patent number
US06242470B1

Reaction notes

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