Nipecotic Acid → 1-Acetyl-3-piperidinecarboxylic acid

HRID 1066309Notes

Reaction equation

[NH:1]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:10]([N:1]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH2:2]1)(=[O:12])[CH3:11]

Participants

Reactant 2

HCID 4498Nipecotic Acid

HCID 7918Acetic Anhydride

Product 1

HCID 140438961-Acetyl-3-piperidinecarboxylic acidYield 97.4%

Procedure

Nipecotic acid (3.87 grams) (30.0 mmoles) was reacted with acetic anhydride (9.17 grams) (90 mmoles) as described in Preparative Example 13A to give the title compound (Yield: 5.0 grams, 97%, MH+ 172).

Sources & evidence

ORD record: ord-e404460836eb4adea77f6dca7aa0cac2
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06242458B1

Reaction notes

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