HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 21198693, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl chlorodifluoroacetate | HCID 73935 | — |
| Reactant | 6-Bromonaphthalen-1-ol | HCID 13215708 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21198693 | HCID 21198693 | 38% |
Reaction Steps
Methyl chlorodifluoroacetate (5.3 mL) was added dropwise to 6-bromonaphthol (10.25 g; 45.9 mmol) and potassium carbonate (7.61g; 55.1 mmol) at 90 C in 160 mL of DMF for 6 h. Purification by gel silica chromatography (3% EtOAc in hexane) gave 4.80 g (38%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242493B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-076c65d97d814f16b73542834d45c17d |
| Source note | uspto-grants-2001_06 |