Potassium Carbonate → HCID 21198693, compound

HRID 1066365Notes

Reaction equation

HRID 1066365 reaction equation
Cl[C:2]([F:8])([F:7])C(OC)=O.[Br:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[C:16](O)=[CH:15][CH:14]=[CH:13]2.C(=O)([O-])[O-:22].[K+].[K+]>CN(C=O)C>[Br:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([O:22][CH:2]([F:8])[F:7])[CH:14]=[CH:13]2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 73935Methyl chlorodifluoroacetateHCID 132157086-Bromonaphthalen-1-ol

Product 1

HCID 21198693HCID 21198693, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl chlorodifluoroacetate (5.3 mL) was added dropwise to 6-bromonaphthol (10.25 g; 45.9 mmol) and potassium carbonate (7.61g; 55.1 mmol) at 90 C in 160 mL of DMF for 6 h. Purification by gel silica chromatography (3% EtOAc in hexane) gave 4.80 g (38%) of the title compound.

Workup

  1. customPurification by gel silica chromatography (3% EtOAc in hexane)

Sources & evidence

ORD record
ord-076c65d97d814f16b73542834d45c17d
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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