Chloroform → HCID 21198682, compound

HRID 1066366Notes

Reaction equation

[Al+3].[Cl-].[Cl-].[Cl-].[Br:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[C:7]=1C.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[C:24](Cl)=[O:25].[CH:27](Cl)(Cl)Cl>>[Br:5][C:6]1[CH:7]=[C:8]([O:12][CH3:27])[CH:9]=[CH:10][C:11]=1[C:24]([C:15]1[CH:16]=[CH:17][C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:14]=1)=[O:25]

Participants

Reactant 4

HCID 6212Chloroform

HCID 752462-Naphthoyl chloride

HCID 6451240Aluminum(III) Chloride

HCID 111714303-Bromo-2-methylphenol

Product 1

HCID 21198682HCID 21198682, compoundYield 47%

Procedure

AlCl3 (17.48 g; 131.1 mmol) was added portionwise to a mixture of 3-bromocresol (16.04 g; 87.4 mmol) and 2-naphthoyl chloride (25.00 g; 131.1 mmol) in 50 mL of CHCl3 gave 14.0 g (47%) of the title compound.

Sources & evidence

ORD record: ord-fb5ca6969f394e9b94b9f96d7b4d59cf
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06242493B1

Reaction notes

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