Benzyl Bromide → HCID 131722613, compound

HRID 1066370Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:15][C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[NH:21][CH:20]=[CH:19]3)=[C:6](/[CH:8]=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=1.[CH2:25](Br)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:15][C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:20]=[CH:19]3)=[C:6](/[CH:8]=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 131722614HCID 131722614, compound

Product 1

HCID 131722613HCID 131722613, compound

Procedure

The indole of Step 1 (621 mg; 1.92 mmol) was coupled with benzyl bromide according to the procedure described in step 1 of example 2 to yield 678 mg of the title compound.

Sources & evidence

ORD record: ord-60be7336d0b6465291122f78aacc89cc
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06242493B1

Reaction notes

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