5-Chloroindole → HCID 131722616, compound

HRID 1066373Notes

Reaction equation

HRID 1066373 reaction equation
Br[CH2:2][C:3]1[C:4](/[CH:9]=[CH:10]/[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:5][CH:6]=[CH:7][CH:8]=1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[CH:20]2>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21]([CH2:2][C:3]1[C:4](/[CH:9]=[CH:10]/[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:5][CH:6]=[CH:7][CH:8]=1)=[CH:20]2

Participants

3

Reactant 2

HCID 871105-ChloroindoleHCID 131722617HCID 131722617, compound

Product 1

HCID 131722616HCID 131722616, compound

Procedure

The benzylic bromide of Step 2 (1.33 g; 4.91 mmol) was coupled with 5-chloroindole according to the procedure described in step 1 of example 2 to yield 1.22 g of the title compound.

Sources & evidence

ORD record
ord-a9c92f243e704ed6bc83b45dc9018f0b
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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