Guanine → Formamide

HRID 1066393Notes

Reaction equation

HRID 1066393 reaction equation
[NH:1]1[C:10](=[O:11])C2NC=NC=2N=C1N.[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([NH:20][CH:21]=[O:22])=[C:15]([OH:23])[N:14]=1>C(O)=O>[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([NH:20][CH:21]=[O:22])=[C:15]([OH:23])[N:14]=1.[CH:10]([NH2:1])=[O:11]

Participants

5

Reactant 2

HCID 135398634GuanineHCID 178508810N-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)formamide

Product 2

HCID 713FormamideHCID 178508810N-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)formamide

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The objects of the invention, and others, may be accomplished with a process for the preparation of guanine starting from 2,4-diamino-5-formylamino-6-hydroxypyrimidine (DAFHP), which comprises reacting isolated DAFHP in the absence of formamide in formic acid, with or without addition of water under reflux conditions, to produce guanine.

Sources & evidence

ORD record
ord-a0cbe2276ea3440cbde73905acc9b8eb
Source dataset
uspto-grants-2001_06
Patent number
US06242599B1

Reaction notes

Loading…