反应详情

To a solution of 5-isopropyl-pyridine-2-sulfonamide potassium salt (synthesis described in EP 0 799 209) in water (10 ml) were added 1.2 g of KMnO4 at RT and the mixture was then refluxed for 30 minutes. The mixture was cooled to RT, acidified with diluted HCl and the product was extracted into AcOEt. The organic layer was washed with washed with water, dried over Na2SO4 and concentrated in vacuo to give (5-(1-hydroxy-1-methyl-ethyl))-pyridine-2-sulfonic acid amide as yellow oil. EI mass spectrum, m/e 216 (M calculated for: C8H12N2O3S 216).

1. temperaturethe mixture was then refluxed for 30 minutes
2. extractionthe product was extracted into AcOEt
3. washThe organic layer was washed
4. washwith washed with water
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo