Ammonia → Octyl 4'-hydroxy-4-biphenylcarboxylate

HRID 1066545Notes

Reaction equation

HRID 1066545 reaction equation
COC([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)=O.N.ClCCl>C(O)C>[OH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])=[CH:14][CH:13]=2)=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6344DichloromethaneHCID 18328376Octyl4'-methoxycarbonyloxy-4-biphenylcarboxylate

Product 1

HCID 14692993Octyl 4'-hydroxy-4-biphenylcarboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of compound 5 (5.25 g, 0.014 mol) and aqueous ammonia (35% w/v, 100 ml) in ethanol (200 ml) was stirred for 1 h at room temperature. TLC analysis (dichloromethane) revealed a complete reaction. The solvent was removed in vacuo and the shite solid was recrystallised from ethanol to give colourless crystals.

Workup

  1. customa complete reaction
  2. customThe solvent was removed in vacuo
  3. customthe shite solid was recrystallised from ethanol
  4. customto give colourless crystals

Sources & evidence

ORD record
ord-4c0928ed998b44f0abc8a9f40a5bde1b
Source dataset
uspto-grants-2001_06
Patent number
US06242636B1

Reaction notes

Loading…