Potassium Carbonate → HCID 22040086, compound

HRID 1066584Notes

Reaction equation

HRID 1066584 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([OH:12])=[C:8]([CH:11]=1)[CH:9]=[O:10])[CH3:2].Br[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([O:12][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:8]([CH:9]=[O:10])[CH:11]=1)[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 84580Ethyl 5-bromovalerateHCID 38657875-ethoxy-2-hydroxybenzaldehyde

Product 1

HCID 22040086HCID 22040086, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2.49 g of 5-ethoxy-2-hydroxy-benzaldehyde, 2.7 ml of ethyl 5-bromovalerate, 15 ml of DMSO, 3.1 g of K2CO3 and 75 mg of KI were stirred for 2.5 hrs. at 55° C. After working up and chromatography on silica gel there were obtained 4.7 g of ethyl 5-(4-ethoxy-2-formyl-phenoxy)-pentanoate. MS: 294 (M)+.

Workup

  1. customat 55° C

Sources & evidence

ORD record
ord-7e040b8fb6244577a9109ef521876fa4
Source dataset
uspto-grants-2001_06
Patent number
US06242644B1

Reaction notes

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