Potassium Carbonate → HCID 22039887, compound

HRID 1066587Notes

Reaction equation

HRID 1066587 reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].C([O-])([O-])=O.[K+].[K+].Cl[CH:19]([OH:21])[CH3:20]>CS(C)=O>[OH:21][CH2:19][CH2:20][O:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 126390351-Chloroethan-1-ol

Product 1

HCID 22039887HCID 22039887, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2.5 g of 2-hydroxy-4-methoxybenzaldehyde, 6.8 g of K2CO3, 3.3 ml of chloroethanol and 33 ml of DMSO were heated for 8 hrs. to 80° C. Extraction with ethyl acetate and chromatography on silica gel with methylene chloride-acetone gave 2.1 g of 2-(2-hydroxy-ethoxy)-4-methoxy-benzaldehyde, m.p. 94° C., MS: 196 (M)+.

Workup

  1. customto 80° C
  2. extractionExtraction with ethyl acetate and chromatography on silica gel with methylene chloride-acetone

Sources & evidence

ORD record
ord-d81dc5d56744402c8a15642722038e63
Source dataset
uspto-grants-2001_06
Patent number
US06242644B1

Reaction notes

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