HRID1066654

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

反应SMILES：CS(=O)(=O)OCCC1(c2ccc(Cl)c(Cl)c2)COC(=O)N(Cc2ccccc2)C1

HCID15886668

未命名化合物

HCID15886675

N-(4-Phenylpiperidin-4-yl)acetamide

C13H18N2O

PRODUCTS

产物

反应SMILES：CC(=O)NC1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)COC(=O)N(Cc3ccccc3)C2)CC1.Cl

HCID21200517

未命名化合物

收率 52.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

This compound is prepared by the procedure described in step D of EXAMPLE 1 from 2.77 g of 4-acetamido-4-phenylpiperidine, 1.7 g of the compound obtained in step C of EXAMPLE 1 and 0.61 g of potassium iodide in 10 ml of DMF. The residue is chromatographed on silica H using DCM and then a DCM/MeOH mixture (97/3; v/v) as the eluent. The residue is taken up with a saturated solution of gaseous HCl in ether and the solvent is evaporated off under vacuum to give 0.6 g of the expected compound after crystallization from AcOEt. M.p.=168° C.

WORKUP

后处理

customThis compound is prepared by the procedure
customThe residue is chromatographed on silica H
customthe solvent is evaporated off under vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-ecb1cd0dbe924af4a9eccdf1afe7d0ea
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06242637B1
来源说明: uspto-grants-2001_06

反应SMILES

[C:1]([NH:4][C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2].[CH2:17]([N:24]1[CH2:29][C:28]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=2)([CH2:30][CH2:31]OS(C)(=O)=O)[CH2:27][O:26][C:25]1=[O:45])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[I-].[K+]>CN(C=O)C>[ClH:43].[C:1]([NH:4][C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6][CH2:7][N:8]([CH2:31][CH2:30][C:28]2([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=3)[CH2:27][O:26][C:25](=[O:45])[N:24]([CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:29]2)[CH2:9][CH2:10]1)(=[O:3])[CH3:2]